Diagram showing neuromuscular junction and action of botulinum toxin A. It illustrates neural transmission, the release of acetylcholine from the nerve to trigger muscle contraction, and how botulinum toxin A blocks this process by cleaving SNARE proteins, preventing acetylcholine release.

So, how does Botox work, and why is its effect temporary?

Botox functions by inhibiting the release of acetylcholine from nerve endings, leading to muscle paralysis. Its action involves protein interaction and takes a few days to fully manifest. However, as new protein production continues, the effects gradually diminish over a period of 4-6 months. Regardless of the dosage administered, achieving permanent results with Botox is not possible due to this mechanism.

A box and a vial of Botox Botulinum Toxin Type A, 100 units, from Allergan